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Association of 1800 cGy Cranial Irradiation with Intellectual Function in Children with Acute Lymphoblastic Leukaemia Lancet 344:224-227, Jankovic,M.,et al, 1994 See this aricle in Pubmed Article Abstract We evaluated 203 children for six years in a multi-centre European study. The patients were divided into two groups;129 children treated with 1800 cGy of cranial radiation therapy and 74 children who received high-dose methotrexate but no radiation therapy.We used full scale intelligence quotient,verbal,and performance IQ tests to assess the patient's intelligence.We found a significant decline in full scale intelligence quotient in the irradiated group that increased with the length of time from diagnosis.Younger age at diagnosis was associated with lower full scale intelligence quotient in the radiated group.Our results indicate that a radiation dose of 1800 cGy can have negative effects on neurocognitive function and we continue to question the benefit of low- dose cranial radiation therapy.

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(click to filter results - removes previous filter) intellectual deficit intellectual deterioration leukemia,neurologic findings assoc.with psychological testing psychological testing,children radiation therapy,CNS treatment and complications with

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