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With the increasing long-term use of interferon,several new adverse effects have been recognized.We have prospectively assessed auditory function in 49 patients receiving interferon,after we saw a case of sudden sensorineural hearing loss during interferon therapy.Auditory disability (tinnitus,hearing loss,or both)occurred in 22 patients(45%)during treatment with audiometry-documented sensorineural hearing loss in 18 (37%).The auditory disability often developed in the late stage of treatment and resolved in all patients within 7-14 days after discontinuation of interferon. |
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