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Thirteen families and 34 women at risk for being carriers of Duchenne and Becker muscular dystrophies were analyzed blind by restriction fragment length polymorphisms(RFLPs)and a new,non-radioactive direct test based on competitive polymerase-chain-reaction(PCR)amplification.All obligate carriers were correctly diagnosed by RFLPs and competitive PCR,and 7 women with a 99%risk of being carriers were also diagnosed carriers by competitive PCR.There were no false positives or false negatives.Only 1 PCR result was noninformative.Our test allows rapid,precise,and direct carrier diagnosis of women whose relatives have a known deletion of the dystrophy gene. |
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dystrophin muscular dystrophy muscular dystrophy,Becker muscular dystrophy,Becker,carrier muscular dystrophy,Duchenne,carrier neurologic disease,diagnoses of polymerase chain reaction RFLPs
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