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The role of early radiotherapy in the treatment of low-grade gliomas is controversial.For this reason,the impact of radiotherapy on quality of life was studies in long-term survivors of biopsy-proved low-grade gliomas without signs of tumor recurrence.Twenty patients(age range,18-66 years) had been treated with early radiotherapy;the other 21 patients(age range 19-65 years)had undergone surgery or biopsy only.The interval from diagnosis to testing ranged from 1 to 12 years(mean 3.5 years).Nineteen patients with low-grade hematological malignancies,surviving 1 to 15 years without central nervous system,involvement,served as control subjects. Apart from the neurological and functional status,the patients'cognitive, affective,and psychological status was determined.None of the survivors had significant neurological impairment and the Karnofsky index for them was at least 70.However,more specific examination of cognitive functions and the affective status(Profile of Mood States)indicated that,compared to the control subjects,the patients with low grade gliomas had significantly more cognitive disturbances and suffered more frequently from fatigue and depressed moods.The two groups with low-grade gliomas,on the other hand, did not differ significantly on any of these measures.It is concluded that radiotherapy did not cause these disturbances and had no negative impact on quality of life in these patients. |
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glioma
glioma,low-grade
neoplasm,primary of CNS
neoplasm,primary of CNS-treatment of
quality of life
radiation therapy,CNS treatment and complications with
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