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Effects of Vigabatrin on Partial Seizures and Cognitive Function JNNP 57:1057-1063, Grunewald,R.A.,et al, 1994 See this aricle in Pubmed Article Abstract Vigabatrin was associated with a significant reduction in a measure of motor speed and overall score on a design learning test in the first 20 weeks of treatment.In comparison with the baseline period,a significant reduction in median complex partial seizure frequency four to 12 and 12 to 20 weeks after commencing vigabatrin(-66%and-69%in the vigabatrin group,+ 50%and_25%in the placebo group).Ten of 20 patients on vigabatrin and four of 23 on placebo showed a>50%reduction in complex partial seizure frequency in the last eight weeks of double blind treatment.At least 60%of the responders had maintained the response to vigabatrin when assessed during the open phase of the trial at 44 weeks.Two patients discontinued vigabatrin because of depression,which resolved on drug withdrawal.

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(click to filter results - removes previous filter) adverse drug reaction anticonvulsants anticonvulsants,cognitive function with depression psychological testing seizure seizure,intractable seizure,intractable,treatment of seizure,psychomotor-temporal lobe seizure,treatment of vigabatrin

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