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Neuropathologic Correlated of Persistent Neurologic Deficit in Lithium Intoxication
Ann Neurol 36:928-931, Schneider,J.A.&Mirra,S.S., 1994
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Article Abstract
While acute neurological symptoms complicating lithium therapy are well recognized,persistent neurologic dysfunction is uncommon.Regardless of the duration of symptoms,neuropathological correlates of lithium toxicity are few.We report the case of a 67-year-old man who developed lithium toxicity manifested by encephalopathy and coma followed by persistent dysarthria and ataxia.Autopsy revealed neuronal loss and gliosis in the cerebellar cortex and dentate nuclei;the cerebellar white matter exhibited prominent spongy change.Persistent cerebellar syndrome may occur with lithium intoxication and should be considered in the differential diagnosis of chronic cerebellar dysfunction.
 
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adverse drug reaction
ataxia
cerebellar lesion
cerebellum,disease of
coma
drug induced neurologic disorders
dysarthria
encephalopathy
lithium
neurologic signs
neuropathology

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