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Migraine Prophylaxis with Divalproex
Arch Neurol 52:281-286, Mathew,N.T.,et al, 1995
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Article Abstract
During the treatment phase,the mean migraine headache frequency per 4 weeks was 3.5 in the divalproex group and 5.7 in the placebo group(P=. 001),compared with 6.0 and 6.4,respectively,during the baseline phase. Forty-eight percent of divalproex-treated patients and 14%of placebo- treated patients showed a 50%or greater reduction in migraine headache frequency from the baseline phase(P<.001).Among those with migraine headaches,divalproex-treated patients reported significantly less functional restriction than placebo-treated patients and used significantly6 less symptomatic medication per episode.No significant treatment group differences were observed in average peak severity or duration of individual migraine headaches.Treatment was stopped in 13%of divalproex-treated patients and 5%of placebo-treated patients because of intolerance(P,not significant).Divalproex is an effective prophylactic drug for patients with migraine headaches and is generally well tolerated.
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headache,treatment of
migraine
migraine,prophylaxis
migraine,treatment of
sodium valproate
treatment of neurologic disorder
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