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Longitudinal MRI in Multiple Sclerosis:Correlation Between Disability and Lesion Burden Neurol 44:2120-2124, Khoury,S.J.,et al, 1994 See this aricle in Pubmed Article Abstract We followed 18 multiple sclerosis patients clinically and with repeated brain MRIs with and without gadolinium for over 1 year.Clinical evaluations included scoring on the Kurtzke Expanded Disability Status Scale(EDSS)and the Ambulation Index(AI)scale.There was a significant correlation between the change in EDSS or AI and the change in number of lesions on MRI and between cumulative number of lesions on MRI and cumulative changes in EDSS or AI.Our findings support the validity of MRI as a measure of clinical activity and potentially as an objective quantitative outcome measure for assessing response to the therapy.

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(click to filter results - removes previous filter) disability,neurological gadolinium MRI MRI,abnormal MRI,contrast enhanced MRI,serial multiple sclerosis multiple sclerosis,disability status scale

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