Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

Serotonin Syndrome
Neurol 45:219-223, Bodner,R.A.,et al, 1995
See this aricle in Pubmed

Article Abstract
We describe a patient treated with trazodone,isocarboxazid,and methylphenidate hydrochloride who developed confusion,agitation,poor concentration,rigidity,myoclonus,involuntary movements,orthostatic hypotension,and hyperreflexia.CK was normal,and the syndrome resolved spontaneously over 12 hours.The serotonin syndrome occurs following the use of serotomimetic agents(serotonin reuptake inhibitors,tricyclic and tetracyclic antidepressants,trytophan,3,4-methylenedioxy-methamphetamine, dextromethorphan,meperidine,S-adenosylmethionine)alone or in combination with monoamine osidase inhibitors.It is characterized by various combinations of myoclonus,rigidity,hyperreflexia,shivering,confusion, agitation,restlessness,coma,autonomic instability,low-grade fever,nausea, diarrhea,diaphoresis,flushing,and,rarely,rhabdomyolysis and death.
 
Related Tags
(click to filter results - removes previous filter)

adverse drug reaction
agitation
coma
confusion
drug induced neurologic disorders
drug interactions
hyperactivity
hyperreflexia
movement disorder
myoclonus
orthostatic hypotension
prognosis
rigidity
selective serotonin reuptake inhibitors
serotonin
serotonin syndrome
shivering
trazodone
treatment of neurologic disorder

Click Here to return To Results