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Patients receiving the twice-weekly regimen had 1.6 times(CI,0.9 to 2.9 times;P=0.11)the adjusted risk for death of patients receiving the daily regimen.No statistical differences were found in the patients who stopped receiving the regimens due to adverse effects.No patient developed P. carinii pneumonia during the study period,even though 17 patients(10 receiving the daily regimen and 7 receiving the twice-weekly regimen)had had an episode of P.carinii pneumonia before study entry.At the given doses,a combination of sulfadiazine,pyrimethamine,and folic acid was less effective when administered twice weekly than when administered daily, although the twice-weekly regimen was much more effective than historic controls. |
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