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Recurrent Stroke and Thrombo-Occlusive Events in the Antiphospholipid Syndrome
Ann Neurol 38:119-124, Levine,S.R.,et al, 1995
See this aricle in Pubmed

Article Abstract
We prospectively studied 81 consecutively identified patients with antiphospholipid antibodies(aPLs)who developed focal cerebral ischemia over a 7-year period.The mean age of this cohort was approximately a decade younger than the average atherothromboembolic stroke victim and women were more commonly involved than men.The frequency of conventional stroke risk factors was lowest in the group of stroke patients with the highest levels of IgG cardiolipin immunoreactivity.Other serological abnormalities associated with aPL(false-positive Veneral Disease Research Laboratory test,thrombocytopenia,prolonged activated partial thromboplastin time[aPTT])were more common in the group with over 100 GPL units(high positive).Patients with the highest IgG anticardiolipin titers had the shortest times to subsequent thrombo-occlusive events.The most common recurrent event was cerebral infarction,often occurring within the first year of follow-up during a mean prospective follow-up of 3 years. Over one-half of the cohort had at least one recurrent thrombo-occlusive event during follow-up.This distinct syndrome of cerebral ischemia should be recognized for its younger age at onset,predominance of women,high risk of recurrent thrombo-occlusive events,and the possible use of the IgG anticardiolipin antibody titer for prognosis.
 
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abortion,spontaneous
ANA
anticardiolipin antibodies
antiphospholipid antibodies
antiphospholipid antibody syndrome
cerebral infarction
cerebral ischemia
cerebrovascular accident
cerebrovascular accident,recurrent
cerebrovascular accident,women
false negative VDRL
hypercoagulable state
lupus anticoagulant
prognosis
review article
thrombocytopenia
transient ischemic attack

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