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Acute Arcuate Fiber Demyelinating Encephalopathy Following Epstein-Barr Virus Infection
Ann Neurol 38:127-131, Paskavitz,J.F.,et al, 1995
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Article Abstract
We describe a patient who presented with an acute monophasic illness characterized by behavioral abnormalities,visual illusions,and a seizure, who had magnetic resonance-and brain biopsy-documented evidence of multifocal central nervous system demyelination.Serological studies were diagnostic of recent Epstein-Barr virus infection and included evidence of intrathecal synthesis of Epstein-Barr virus-specific IgG antibodies against the viral capsid antigen.Viral DNA could not be amplified from cerebrospinal fluid by polymerase chain reaction,and viral antigen and genome were not detested in the brain biopsy specimen.The patient's clinical course,diagnostic studies,and neuropathological findings all support the diagnosis of a postinfectious Epstein-Barr virus-mediated demyelinating encephalopathy.
 
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acute disseminated encephalomyelitis
brain biopsy
encephalitis
encephalomyelitis,postinfectious
encephalopathy
Epstein-Barr virus
infectious mononucleosis
mania
MRI
MRI,abnormal
personality change
psychosis
psychosis,acute
seizure

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