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We studied by magnetic resonance spectroscopy 19 boys(aged 76-167 months) diagnosed as having DMD and 19 control boys of similar age(87-167 months) diagnosed as having DMD and intelligence quotient(IQ)was assessed with the Wechsler Intelligence Scale for children.The DMD patients had significantly higher values than the controls in the brain ratios of inorganic phosphate to adenosine triphosphate(mean 0.53[SD 0.21]vs 0.36[0. 09],p=0.003),to phosphomonoesters(.040[0.07]vs 0.29[0.07],p=0.0001),and to phosphocreatine(0.44[0.10]vs 0.37[0.08],p=0.02).There were significant differences between the DMD patients and the controls in full-scale IQ(76[ 16]vs 101[16],p=0.0001),performance IQ(78[17]vs 94[14],p=0.003),and verbal IQ(78[17]vs 106[17],p=0.0001).These altered metabolite ratios parallel the findings in dystrophic muscle and suggest bioenergetic similarities in tissue that lack dystrophin. |
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