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Inclusion body myositis developed in two men,36 and 48 years old with long-standing common variable immunodeficiency.We conclude that inclusion body myositis can develop in patients with common variable immunodeficiency.Common variable immunodeficiency with inclusion body myositis is an immune myopathy mediated by NK cells in a non-MHC class I- restricted cytotoxicity,and by CD8+cells in an MHC class I-restricted process.This is the first description of an inflammatory myopathy in which NK cells participate in the myocytotoxic process. |
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