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Manganese and Chronic Hepatic Encephalopathy Lancet 346:270-274, Krieger,D.,et al, 1995 See this aricle in Pubmed Article Abstract Whole blood Mn concentrations in patients with liver cirrhosis were significantly increased(median 34.4 ug/L vs 10.3 ug/L in controls;p=0. 0004)and pallidal signal intensity indices correlated with blood Mn(Rs=0. 8,p=0.0058).Brain tissue samples reveal highest Mn concentrations in the caudate nucleus,followed by the quadrigeminal plate and globus pallidus.Mn accumulates within the basal ganglia in liver cirrhosis.Similarities between Mn neurotoxicity and chronic hepatic encephalopathy suggest that this metal may have a role in the pathogenesis of chronic hepatic encephalopathy.Further studies are warranted because the use of chelating agents could prove to be a new therapeutic option to prevent or reverse this neuropsychiatric syndrome.

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