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Leptomeningeal Tumor in Primary CSN Lymphoma:Recognition, Significance, and Implications
Ann Neurol 38:202-209, Balmaceda,C.,et al, 1995
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Article Abstract
The incidence of leptomeningeal tumor was 42%at diagnosis and 41%at recurrence.Only elevated levels of protein and lactate dehydrogenase isoenzyme-5 were significantly associated with leptomeningeal tumor(p=0. 012,p=0.016,respectively).Treatment against the leptomeninges was significantly associated with the probability of achieving a complete response and a longer freedom from relapse.Patients older than 50 years had a worse disease-specific survival but a similar probability of responding to therapy as younger patients.Our data show that leptomeningeal tumor in primary central nervous system lymphoma is more prevalent than originally thought,and indicate the need for therapy inclusive of the leptomeninges in all patients.
 
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cerebrospinal fluid
cerebrospinal fluid,cytology
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lumbar puncture
lymphoma
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lymphoma,primary of CNS
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MRI,abnormal
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