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The Course of Seizure Disorders in Patients with Malignant Gliomas Arch Neurol 52:717-724, Moots,P.L.,et al, 1995 See this aricle in Pubmed Article Abstract Twenty-nine patients presented with seizures,and 21 of these had subsequent(eg,"recurrent")seizures while they were receiving anticonvulsant therapy.Ten of 36 patients who were free of seizures at diagnosis experienced seizures after diagnosis(eg,"late onset")while they were being treated with anticonvulsants,including five patients who had single seizures.Long-term seizure frequency in excess of one per month was observed in 13 patients.Ten patients had episodes of partial motor status epilepticus.Most recurrent and late-onset seizures occurred despite therapeutic anticonvulsant levels,and without evidence of tumor progression.Rash associated with anticonvulsants was observed in 26%of the patients.Other clinically important toxic side effects were observed in 14%of the patients who were receiving long-term anticonvulsant therapy. Seizures contributed substantially to the neurologic morbidity of MGs in at least 25%of these patients.The occurrence of seizures at diagnosis was a strong predictor of subsequent seizures,and in many patients,seizures proved to be refractory to standard anticonvulsant therapy.Long-term anticonvulsant toxic side effects are relatively common in patients with MGs.The use of long-term seizure prophylaxis for patients with MGs who are free of seizures at presentation is not clearly beneficial and should be studied in a prospective trial.

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(click to filter results - removes previous filter) anticonvulsants astrocytoma glioblastoma multiforme(astrocytoma Gr.III) glioma neoplasm,primary of CNS seizure seizure,treatment of

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