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Heavy users displayed significantly greater impairment than light users on attentional/executive functions,as evidenced particularly by greater perseverations on card sorting and reduced learning of word lists.These difference remained after controlling for potential confounding variables, such as estimated levels of premorbid cognitive functioning,and for use of alcohol and other substances in the two groups.Heavy marijuana use is associated with residual neuropsychological effects even after a day of supervised abstinence from the drug.However,the question remains open as to whether this impairment is due to residue of drug in the brain,a withdrawal effect from the drug,or a frank neurotoxic effect of the drug. |
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