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In a person with now family history of AD,the epidemiologic/actuarial lifetime risk of AD is approximately 15%.Based on a Bayesian calculation and published APEO data,the lifetime risk of AD is 29%for individuals with one APOE*e4 allele and it is 9%if no APEe*e4 allele is present.Physician awareness survey results were as follows:42%of physicians correctly estimated that approximate lifetime risk of AD;of these,only one third were moderately sure of their response.Only three physicians correctly estimated the change in risk given to the APOE*e4 genotype,only one of these was at least moderately sure.Determining APOE*e4 status of healthy adults with no family history of AD approximately doubles(for the e4 allele)or reduces by 40%(for the non-e4 allele).,the uninformed lifetime risk of developing AD.Even with an APOE*e4 allele,the lifetime risk remains below 30%.Most physicians managing patients with AD do not know the lifetime risk of AD,and very few know how APOE*e4 status modifies the risk.These clinically relevant risk figures should be more widely disseminated among physicians. |
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