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Statistically significant differences were found in neurofibrillary tangle densities in the superior parietal,superior temporal,anterior and posterior cingulate cortex,and nucleus basalis of Meynett between nondemented and Alzheimer's disease cases.The superior parietal and posterior cingulate cortex contained significantly higher senile plaque counts in demented compare with nondemented cases.In contrast to younger demented cases,the number of senile plaques in the neo-cortex was correlated with the severity of dementia in centenarians.These results indicate that the neuronal degeneration in very old demented patients involves cortical areas usually preserved at the early stages of the dementing process.Senile plaque formation in certain neo-cortical areas may be a pathologic hallmark of the severity of dementia in this particular age group. |
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