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Acquired Neuromyotonia:Evidence for Autoantibodies Directed Against K+Channels of Peripheral Nerves
Ann Neurol 38:714-722, 7011995., Shillito,P.,et al, 1995
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Article Abstract
Acquired neuromytonia is characterized by hyperexcitability of motor nerves leading to muscle twitching,cramps,and weakness.The symptoms may improve following plasma exchange,and injection of immunoglobulin G(IgG) from 1 neuromyotonia patient into mice increased the resistance og neuromuscular transmission of d-tubocurarine.We conclude that at lease some patients with acquired neuromyotonia have antibodies directed against aminopyridine-or alpha-dendrotoxin-sensitive K+channels in motor and sensory neurons,and they are likely to be implicated in the disease process.
 
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autoantibodies
creatine phosphokinase(CPK)elevated
electromyogram
Isaacs syndrome
muscle cramp
muscle stiffness
muscle twitching
muscle weakness
myokymia
neuromyotonia
ophthalmoplegic migraine
potassium channel antibodies

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