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Aspirin is commonly used to treat migraine attacks,although sumatriptan,a much more expensive treatment,is also effective.We compared a combination of lysine acetylasalicylate(equivalent to 900 mg aspirin)and 10 mg metoclopramide(LAS+MTC)with oral sumatriptan(100 mg)and placebo in 421 patients with migraine.LAS+MTC was as effective as sumatriptan with a decrease of headache from severe or moderate to mild or none of 57%and 53%,respectively,for the first migraine attack treated.Both treatments were better than placebo(success rate 24%,p<0.0001).LAS+MTC was significantly more effective in the treatment of nausea than sumatriptan (p<0.0001)and was better tolerated(adverse events in 18%and 28% respectively,p<0.05).LAS+MTC is as effective as sumatriptan in the treatment of migraine attaches.It is also cheaper. |
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