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In Utero Exposure to Phenobarbital and Intelligence Deficits in Adult Men
JAMA 274:1518-1525, Reinisch,J.M.,et al, 1995
See this aricle in Pubmed
Article Abstract
Men exposed prenatally to phenobarbital had significantly lower verbal intelligence score(approximately 0.5 SD)than predicted.Lower socioeconomic status and being the offspring of an"unwanted"pregnancy increased the magnitude of the negative effects.Exposure that included the last trimester was the most detrimental.Phenobarbital exposure during early development can have long term deleterious effects on cognitive performance.Detrimental environmental conditions can interact with prenatal biological insult to magnify negative outcomes.Physicians are urged to use increased caution in prescribing such medications during pregnancy.
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adverse drug reaction
anticonvulsants
anticonvulsants,cognitive function with
anticonvulsants,untoward effects of
cognition
intellectual deficit
intelligence quotient
intrauterine
phenobarbital
psychological testing
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