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Decreased Corpus Callosum Size Among Alcoholic Women Arch Neurol 53:359-363, Hommer,D.,et al, 1996 See this aricle in Pubmed Article Abstract Females had smaller intracranial areas than males,but there was no difference in intracranial area between the alcoholics and nonalcoholic. The corpus callosum area was significantly smaller among the alcoholic woman compared with either the control women or the alcoholic men. Alcoholic men did not differ from control men in the corpus callosum area. These results did not change when the corpus callosum area was adjusted for intracranial area by analysis of covariance.When the corpus callosum was divided into four segments of equal length,the reduction in area was not localized to any particular region.These results suggest an increased sensitivity to alcohol-induced brain damage among alcoholic women compared with alcoholic men.

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