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A 22-year-old woman gradually developed depression,dementia,and chorea over an 8-month period.She fulfilled the criteria for the primary antiphospholipid antibody syndrome but not those for systemic lupus erythematosus.Her chorea and neurobehavioral deficits responded favorably to a regimen of prednisone,hyhdroxychloroquine,and aspirin.This appears to be the first report of a patient with a lupus anticoagulant and reversible dementia.The response to immunosuppressive therapy implies an antibody- mediated condition similar to Sydenham's chorea. |
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