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The Management of Brainstem Gliomas in Patients with Neurofibromatosis 1 Neurol 46:1652-1660, Pollack,I.F.,et al, 1996 See this aricle in Pubmed Article Abstract We conclude that the biological behavior of brainstem lesions in patients with NF1 differs significantly from that of lesions with a similar appearance in patients without this disorder.Although these lesions may at some time in their course exhibit clinical and radiographic progression, most do not require specific intervention.The lesions that are most likely to progress and require therapy are focal enhancing tumors;however,even lesions in this subgroup may stabilize in size or regress spontaneously without intervention.Based on these results,we recommend that intervention be limited to those lesions that exhibit rapid or unrelenting growth on serial images or that produce significant clinical deterioration.

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