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Varicalla-Zoster Virus DNA in CSF & Arteries in Delayed Contralat Hemiplegia:Evid for Viral Invasion of Cerebr Art
Neurol 47:569-570, Melanson,M.,et al, 1996
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Article Abstract
A 78 year old woman presented with a right basal ganglia infarct 6 weeks after a left herpes zoster ophthalmicus.MR angiography showed focal segmental stenosis of the proximal segments of the anterior,middle and posterior cerebral arteries.Varicella DNA was detected in the CSF by polymerase chain reaction(PCR).Treated with dexamethasone and acyclovir without improvement,she died one month later.There was focal endarteritis in the left anterior,middle and posterior cerebral arteries at autopsy. Varicella DNA was detected by PCR of extracts from these vessels but not from the arteries on the right side.This study provides further evidence that the vasculopathy after herpes zoster ophthalmicus results from direct viral invasion of the vessel wall.
 
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arteritides
cerebral infarction
cerebrospinal fluid
cerebrospinal fluid,abnormal
cerebrovascular accident
cerebrovascular accident,delayed onset
hemiplegia
herpes zoster
herpes zoster,ophthalmicus
MRI
MRI,abnormal
MRI,angiography
polymerase chain reaction
varicella zoster virus
varicella zoster virus,vasculopathy
vasculitides
vasculopathy

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