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Fifty-nine of the 288 children treated with artemether died in the hospital(20.5%)as compared with 62 of the 288 treated with quinine(21.5%). Among the 418 children analyzed at approximately five months for neurologic disease,residual neurologic sequelae were detected in 7 of 209 survivors treated with artemether(3.3%)and 11 of 209 survivors treatment with quinine(5.3%,P=0.5).After adjustment for potential co-founders,the odds ratio for death was 0.84(05%confidence interval,0.53 to 1.21)in the artemether group,and for residual neurologic sequelae,0.51(95%confidence interval,0.17 to 1.47).There were fewer local reactions at the injection site with artemether than with quinine(0.7%vs 5.9%,P=0.001.)Artemether is as effective as quinine in the treatment of cerebral malaria in children. |
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artemether
central nervous system,infection of
malaria
malaria,cerebral
parasitic infection,CNS
quinine
treatment of neurologic disorder
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