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Therapy of Primary CNS Lymphoma with Methotrexate-Based Chemotherapy and Deferred Radiotherapy:Prelimary Results Neurol 46:1757-1759, Cher,L.,et al, 1996 See this aricle in Pubmed Article Abstract Disease-free survival in primary CNS lymphoma has improved with the advent of methotrexate-based pre-irradiation chemotherapy.Prolonged response durations have been noted in six of eight patients refusing radiation therapy in two of our prior series.We have treated an additional 11 patients with methotrexate-based chemotherapy without subsequent planned irradiation.Some received maintenance chemotherapy.Most have had durable responses with little or no toxicity.Prolonged responses can be maintained without radiation therapy,thus avoiding potential long term radiation toxicity.

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(click to filter results - removes previous filter) chemotherapy,CNS treatment and complications with lymphoma lymphoma involving CNS methotrexate neoplasm,primary of CNS neoplasm,primary of CNS-treatment of treatment of neurologic disorder

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