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the anti-epileptic effect of vigabatrin as a first choice therapy was investigated in 6 children suffering from infantile spasms(IS).All 6 children showed a reduction in seizure frequency.Three children became seizure-free within a period of 2 weeks.Because our results suggest"an all or nothing phenomenon",a period of 2 weeks may be sufficient to evaluate the efficacy of vigabatrin in untreated infants suffering from IS.We suggest to use vigabatrin as a first choice anti-epileptic drug in infants with IS. |
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