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Seventy-four of 75 consecutive eligible patients were entered in this study.Median follow-up was 7 months.The drug and placebo groups did not differ significantly in age,sex,KPS,primary tumor type,number or location of brain lesions,frequency of brain surgery,or pretreatment EEG.Thirteen of 37 patients(35%)receiving divalproex sodium and 9 of 37 patients(24%)on placebo had seizures.The odds ratio for a seizure in the divalproex sodium arm relative to the placebo arm was 1.7(95%CI 0.6 to 4.6;p=0.3).The hypothesis that anticonvulsant prophylaxis provides a reduction in the frequency of first seizure as small as 30%was rejected(p=0.05). Anticonvulsant prophylaxis with divalproex sodium is not indicated for patients with brain tumors who have not had seizures. |
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anticonvulsants
neoplasm,metastatic to CNS
neoplasm,primary intracerebral
neoplasm,primary of CNS
seizure
seizure,prevention of
sodium valproate
treatment of neurologic disorder
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