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Serum and cerebrospinal fluid(CSF)samples were obtained after informed consent from relatives of suspected cases of CJD referred to the German CJD surveillance unit.CSF samples from 58 definite(neuropathologically verified),46 probable,and 34 possible CJD cases,and from 44 patients with CJD were analysed by two-dimensional gel electrophoresis(2-DE).Two investigators blinded to clinical findings recorded the presence of two proteins,p130/131.2-DE for p130/131 is a specific test for the diagnosis of CJD.These data suggest including detection of p130/131 as a criterion for the diagnosis of probable CJD in addition to the currently accepted criteria of a rapidly progressive dementia of less than 2 years duration, typical neurological signs,and periodic sharp-wave complexes in the EEG. |
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cerebrospinal fluid
cerebrospinal fluid,abnormal
cerebrospinal fluid,enzymes in
cerebrospinal fluid,protein of
dementia
dementia,diagnostic evaluation of
dementia,rapidly progressive
electrophoretic pattern,CSF
enolase
Jakob-Creutzfeldt disease
Jakob-Creutzfeldt disease,variant
misdiagnosis
neurologic disease,diagnoses of
neuron specific enolase
prion disease
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