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Unusual MRI & Pathologic Findings of PML Complicating Adult Wiskott-Aldrich Syndrome
Neurol 48:279-282, Matsushima,T.,et al, 1997
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Article Abstract
We present a long-surviving patient with Wiskott-Aldrich syndrome complicated by atypical progressive multifocal leukoencephalopathy(PML). MRI showed multiple tiny spots of Gd-DTPA-enhanced lesions on the T1- weighted image.Pathologic findings for brain biopsy were patchy demyelinated vascularized lesions infiltrated by a surprising number of eosinophils.The presence of polyomavirus JC was confirmed by in situ hybridization and polymerase chain reaction.PML should be included in the differential diagnosis when Gd-DTPA-enhanced spotty lesions are present in the white matter,especially in patients who have a mild immunologic defect.
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gadolinium
immunologic disease
immunosuppression
MRI
MRI,abnormal
MRI,contrast enhanced
neuropathology
progressive multifocal leucoencephalopathy
Wiskott-Aldrich syndrome
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