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Regional Subacute Cranial Neuropathies Following Internal Carotid Cisplatin Infusion
Neurol 47:1088-1090, Alderson,L.M.,et al, 1996
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Article Abstract
The interolateral trunk arises from the internal carotid artery at C-4 and provides vascular supply to cranial nerve III to VI.We report a patient who developed neuropathies of cranial nerves III,V,and VI,48 hours after infusion of cisplatin into the right internal carotid artery for an anaplastic oligoastrocytoma.The clinical and radiographic findings implicated direct toxicity to nerves in the distribution of the inferolateral trunk.We found additional cases by review of published brain tumor chemotherapy trials,thus identifying a novel,toxic neurovascular mechanism for injury to cranial nerves III to VI.
 
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abducens nerve paralysis
adverse drug reaction
chemotherapy,CNS treatment and complications with
chemotherapy,intra-arterial
cis-platinum
cranial nerve palsies
cranial neuropathy
cranial neuropathy,multiple
iatrogenic neurologic disorders
neuropathy,toxic
neurotoxic
ophthalmoplegia
third nerve palsy
third nerve palsy,pupil sparing in
trigeminal neuropathy

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