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Low-Dose Clozapine Improves Dyskinesias in Parkinson's Disease Neurol 48:658-662, Durif,F.,et al, 1997 See this aricle in Pubmed Article Abstract The severity of parkinsonian motor disability and dyskinesia was evaluated in seven levodopa-responsive patients with Parkinson's disease after an acute challenge with the mixed dopamine agonist apomorphine,before and after low dose clozapine(50 mg)for 18+/-days.There was a significant 59% improvement of apomorphine-induced dyskinesias without aggravation of parkinsonian motor disability following clozapine treatment.The results suggest that low-dose clozapine,already shown to improve psychotic symptoms,may help to reduce severe levodopa-induced dyskinesia in parkinsonian patients.

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(click to filter results - removes previous filter) clozapine dyskinesia dyskinesia,drug induced L-dopa L-dopa,drug interactions with and side effects of movement disorder,treatment of Parkinson disease treatment of neurologic disorder

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