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Results indicate significant decreases over time in caudate,putamen,and total basal ganglia volume.Age at onset and length of trinucleotide repeat correlated significantly with amount of volume change in caudate and total basal ganglia,even after controlling for length of interimage interval, duration of disease and measures of symptom severity.Amount of change in basal ganglia structures was not significantly correlated with neurologic symptom severity at the time of the initial imaging or duration of symptoms.This is the first longitudinal MRI study to document progressive basal ganglia atrophy in HD,and suggests that quantitative neuroimaging with serial MRI may be useful in monitoring effectiveness of potential treatments.In addition,demonstration of greater rate of basal ganglia atrophy in patients with earlier symptom onset suggests that treatment effects may be more quickly observed in this subgroup than in the general HD population. |
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basal ganglia
basal ganglia,degeneration
basal ganglia,lesion of
Huntington's chorea
MRI
MRI,abnormal
MRI,serial
MRI,volumetry
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