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Direct Endovascular Thrombolytic Therapy for Dural Sinus Thrombosis:Infusion of Alteplase AJNR 18:639-645, Kim,S.Y.&Suh,J.H., 1997 See this aricle in Pubmed Article Abstract Successful recanalization with improvement of symptoms was achieved in all cases.Time required for complete thrombolysis was between 8 and 43 hours. The total dose of Alteplase ranged from 50 mg to 300 mg.Complications of a small intrapelvic hemorrhage and oozing at a femoral puncture site occurred in separate cases,but were not related to the amount of infused alteplase.MRI venograms obtained 1 to 4 weeks after the procedure showed no evidence of reocclusion of the dural sinuses.Direct fibrinolytic therapy with alteplase is safe,fast and effective in treating dural sinus thrombosis.However,to prevent hemorrhagic complications,further studies are required to determine its optimal dose and proper rate of administration.

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(click to filter results - removes previous filter) cerebral venous thrombosis cerebral venous thrombosis,deep cerebrovascular accident cerebrovascular accident,thrombolytic agents in treatment dural sinus thrombosis endovascular therapy fibrinolytic agents fibrinolytic agents,intra-venous local infusion MRI MRI,abnormal MRI,venography neuroradiology,interventional recanalization,venous superior sagittal sinus thrombosis tissue plasminogen activator,intravenous treatment of neurologic disorder

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