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A presymptomatic history of HT is a major feature in the clinical history of progressive supranuclear palsy and may be a diagnostic criterion.Its significance is unknown,but adrenergic nuclei of the brainstem are severely affected,and HT may be the first symptom arising from involvement of these nuclei.This could also explain the features of small vessel disease seen on computed tomography or magnetic resonance imaging in 50%of our patients,as in previous reports. |
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