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The maximal paralysis 2 weeks postinjection with 320 to 480 mouse units (MU)of BTXB was 50 to 75%whereas maximal paralysis was 70 to 80%with 7.5 to 10 MU to BTXA.Postexercise M wave facilitation on day 9 post injection averaged 63%for BTXB and 20%for BTXA.Seven weeks post injection,BTXB- induced paralysis had improved by 66%with complete improvement by 11 weeks postinjection,where as BTXA-induced paralysis had improved by on 6%at 7 weeks,and at 57 weeks postinjection 22%of the original muscle paralysis was still present.Thus,human muscle paralysis resulting from BTXB injection is not as complete or long-lasting as that resulting from BTXA. |
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