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Midline Cerebral Morphometry Distinguishes Frontotemporal Dementia and Alzheimer's Disease Neurol 48:978-985, Kaufer,D.I.,et al, 1997 See this aricle in Pubmed Article Abstract We investigated and contrasted midline cerebral structures in frontotemporal dementia(FTD)and Alzheimer's disease(AD).FTD and AD may be difficult to distinguish clinically.FTD typically affects frontal and anterior temporal regions,whereas AD tends to involve more posterior temporal and parietal areas.We hypothesized that disease-specific cerebral alterations would be differentially reflected in corresponding regions of the corpus callosum(CC),pericallosal CSF space(PCS),or their ratio(CC: PCS).A discriminant model using two ROI variables correctly classified 91% of AD and FTD patients,comparing favorably with blind clinical MRI diagnostic ratings.Midline cerebral structural alterations reflect differential patterns of cerebral degeneration in AD and FTD,yielding morphometic indices that may facilitate the study of brain-behavior relationships and differential diagnosis of dementia.

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(click to filter results - removes previous filter) Alzheimer's disease corpus callosum corpus callosum,atrophy of dementia dementia,clinical diagnosis dementia,differential diagnosis of dementia,frontotemporal MRI MRI,abnormal

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