Peripheral Neuropathy in HIV Infected Patients with the Diffuse Infiltrative Lymphocytosis Syndrome

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Peripheral Neuropathy in HIV Infected Patients with the Diffuse Infiltrative Lymphocytosis Syndrome
Ann Neurol 41:438-445, Moulignier,A.,et al, 1997 See this aricle in Pubmed

Article Abstract
A subset of human immunodeficiency virus(HIV)-infected patients develop persistent CD8 hyperlymphocytosis and a Sjogren's syndrome-like syndrome associated with multivisceral CD8 T-cell infiltration,known as the diffuse infiltrative lymphocytosis syndrome(DILS).Patients with DILS tend to have higher CD4 cell counts,few opportunistic infections,and longer survival times than other HIV-infected patients.Peripheral nerve involvement in DILS has been poorly documented.We studied 12 HIV-infected patients with CD8 hyperlymphocytosis,DILS,and clinical signs of peripheral neuropathy. Two of four patients who were HLA typed were HLA-DR5 and one was HLA-DR6. All patients had the sicca syndrome with multivisceral involvement.The neuropathy was acute or subacute,always painful,and symmetrical in 8 casts.Electrophysiology was consistent with axoal neuropathy in 10 of 12 patients.Nerve biopsy showed marked angiocentric CD8 infiltrates without mural necrosis(12 of 12),and abundant expression of HIV p24 protein in macrophages(12 of 12).The HIV genome was detected by polymerase chain reaction in nerve homogenates.Zidovudine therapy was associated with improvement in 6 of 6 patients and steroid therapy was beneficial in 4 of 5 patients.No T-cell lymphoma was observed during follow-up,but 2 patients developed a primary B-cell lymphoma.We conclude that DILS neuropathy represents HIV-associated neuropathy,characterized by marked CD8 infiltration and abundant HIV in nerve,that improves with zidovudine or steroid therapy,and probably reflects a systemic host-determined and antigen-driven response to HIV.

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