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Prompted by the findings of previous studies with positron emission tomography and a single photon emission computed tomography,which demonstrated hypoperfusion or hyperperfusion in the left temporal lobe in isolated patients with transient global amnesia(TGA),we compared the sensitivity of diffusion-weighted(DW)magnetic resonance imaging(MRI)with that of conventional T1-and T2-weighted MRI in patients with TGA.Ten patients with the typical syndrome of a pure TGA were included in the study.For all patients,a coronal DW sequence,a steady-state free precession(SSFP)sequence,a conventional T1-and T2-weighted turbo spin-echo sequences were obtained.Seven of the 10 patients had elevated signal intensity in the left hippocampal region on DW MRI;moreover,3 of these 7 patients exhibited bilateral signal abnormality in this sequence.All conventional T1-and T2-weighted images as well as all followup studies were normal.The signal elevation in DW MRI correlates with a decrease in the interstitial space and with cellular edema in the temporal lobe during TGA.The underlying pathomechansim causing this cellular edema cannot be clearly out-lined using DW MRI.Our data are,however,compatible with spreading depression.This is the first study to show that DW MRI is a sensitive MRI method for evaluating TGA,especially in the early stage of the disease. |
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hippocampus
MRI
MRI,abnormal
MRI,diffusion weighted
MRI,disappearing lesion on
MRI,functional
precipitating factors
spreading cortical depression
temporal lobe
temporal lobe,lesion
temporal lobe,lesion,bilateral
transient global amnesia
transient global amnesia,precipitating events
transient neurologic deficit
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