Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

Thrombolysis-Related Intracranial Hemorrhage, Analysis of 224 Cases from GUSTO-1 Trial with Clin Correl
Stroke 29:563-569, Gebel,J.M.,et al, 1998
See this aricle in Pubmed

Article Abstract
Most hemorrhages were large(median[25th,75th percentile]volume,72 mL[39, 118]),solitary(66%),lobar(77%),confluent(80%),and intraparenchymal(82%) with a blood/fluid level(82%)and little edema(median[25th,75th percentile] volume,9 mL[5,16]).Hydrocephalus(P<.001),any one mass effect feature(P<. 001),intraventricular hemorrhage(P=.022),mottled hematoma appearance(P=. 050),and hematoma blood/fluid level(P<.001)were associated with higher hemorrhage volume in the radiographic analysis,as were older age(P=.005), treatment with combined streptokinase and tissue plasminogen activator(P=. 034),and hemorrhage onset 8 to 13 hours after treatment(P=.008)in the clinical analysis.Subdural hemorrhage was a high-volume subgroup whose risk increased with antecedent trauma(P=.026)or syncope(P=.006).Deep intraparenchymal hemorrhage was associated with hypertension(P=.016),and multifocal ICH occurred significantly earlier after treatment(P=.002). Although the majority of postthrombolytic ICH are large,solitary,and supratentorial,the spectrum is diverse.Features of mass effect reflected the large volumes,and hematoma characteristics of mottling and blood/fluid levels were frequent.Thrombolysis-related coagulopathy and age appear to be the most important identifiable factors in the genesis of postthrombolytic ICH,but the hemorrhage subtype seen may reflect an interaction with other factors such as hypertension,ICH timing,antecedent head trauma,and syncope.
 
Related Tags
(click to filter results - removes previous filter)

adverse drug reaction
CAT scan
CAT scan,abnormal
cerebellar hemorrhage
coronary thrombolysis
fibrinolytic agents
fibrinolytic agents,complications
head injury
hydrocephalus
hypertension
iatrogenic neurologic disorders
intracerebral hemorrhage
intracerebral hemorrhage,lobar
intracerebral hemorrhage,multiple
intracerebral hemorrhage,volume
intracranial hemorrhage
myocardial infarction
myocardial infarction,acute
review article
risk factors
streptokinase
subdural hematoma
syncope
tissue plasminogen activator,intravenous

Click Here to return To Results