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Of 105 patients who underwent angiography,59 were excluded from randomization.Among the 46 patients randomized,40 were treated with rpro- UK(n=26)or placebo(n=14)a median of 5.5 hours from symptom onset. Recanalization was significantly associated with rpro-UK(2P=.017). Hemorrhagic transformation causing neurological deterioration within 24 hours of treatment occurred in 15.4%of the rpro-UK-treated patients and 7. 1%of the placebo-treated patients(2P=.64).Both recanalization and hemorrhage frequencies were influenced by heparin dose.Intra-arterial local rpro-UK infusion was associated with superior recanalization in acute thrombotic/thromboembolic stroke compared with placebo.In this regimen,heparin dose influenced hemorrhage frequency and recanalization. Although symptomatic hemorrhage remains a concern,this study suggests that recanalization is enhanced with rpro-UK and heparin. |
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adverse drug reaction
angiography,cerebral
cerebrovascular accident
cerebrovascular accident,acute management of
cerebrovascular accident,thrombolytic agents in treatment
endovascular therapy
fibrinolytic agents
fibrinolytic agents,complications
fibrinolytic agents,intra-arterial local infusion
intracerebral hemorrhage
middle cerebral artery territory infarction
middle cerebral artery,occlusion of
recanalization,arterial
treatment of neurologic disorder
urokinase
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