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Acute Stroke:Usefulness of Early CT Findings Before Thrombolytic Therapy Radiology 205:327-333, von Kummer,R.,et al, 1997 See this aricle in Pubmed Article Abstract In 215 patients with a small hypoattenuating area,treatment increased the chance of good outcome.In 336 patients with a normal CT scan and in 52 patients with a large hypoattenuating area,rt-PA had no beneficial effect but increased the risk for fatal brain hemorrhage.The response to rt-PA in patients with ischemic stroke can be predicted on the basis of initial CT findings of the extent of parenchymal hypoattenuation in the territory of the middle cerebral artery.

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