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34 of 40(85%)women with cerebral sinus thrombosis used oral contraceptives,versus 1007 of 2248(45%)of the control women;the age adjusted odds ratio was 13(95%confidence interval 5 to 37).Seven of 36 patients(19%)had a prothrombotic deficiency,versus 7%expected in the population;this corresponds to a three fold to fourfold increase in risk. In women who used oral contraceptives and also carried a prothrombotic defect,the odds ratio for cerebral sinus thrombosis was about 30 relative to women who had neither risk factor. |
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