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Overingestion of isoniazid can cause confusion,slurred speech,seizures, coma,and death.Most cases of a central nervous system toxic reaction due to isoniazid use result from sudden intentional or accidental overdose.We describe a patient taking 1200 mg of isoniazid daily for 6 weeks who presented to the hospital with confusion and lethargy that progressed to coma.Within 30 minutes of receiving 1 g of intravenous pyridoxine hydrochloride,the patient was fully alert and lucid.The diagnosis of a toxic reaction to isoniazid was delayed by the possibility of concurrent active neurosyphilis and the failure to initially consider isoniazid poisoning in a patient without a history of sudden isoniazid overdose. |
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