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Brain Involvement in Scleroderma, Two Autopsy Cases Stroke 29:719-721, Heron,E.,et al, 1998 See this aricle in Pubmed Article Abstract A 41-year-old woman with CREST syndrome developed signs of dementia after an episode of severe dehydration and died two months later of septic shock.A 63-year-old woman with CREST syndrome and a history of two unexplained transient ischemic attacks had had balance disorders since age 62.She died of severe pulmonary hypertension.In both cases,the autopsy showed extensive wall calcification of small arteries and arterioles in the brain,primarily in the basal ganglia,and also in the frontal lobes and the cerebellar area in the second case.No known cause of cerebrovascular calcification was found in either patient.The neuropathological findings in these two patients suggest that systemic sclerosis may induced primary vascular changes in the brain,of which calcification may be a marker.

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(click to filter results - removes previous filter) basal ganglia,calcification of calcification,intracranial cerebral vasculature,calcification CREST syndrome neuropathology scleroderma scleroderma,neurologic involvement with

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