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All patients presented acutely with new seizures or changes in mental status.A history of drug abuse was elicited in seven of the nine remaining patients.Renal failure was present in six cases.Symmetric bilateral caudate and putamen hyperintensity on T2-weighted images was found in all cases with variable extension to the surrounding white matter,thalamus,and brain stem.Postmortem neuropathologic examination in two cases revealed numerous microinfarcts in a distribution similar to the MR signal abnormalities.The MR appearance of basal ganglia hyperintensity in this series of AIDS patients represents ischemic tissue injury.We propose that this clinicopathologic entity is precipitated by the combined effects of human immunodeficiency virus infection and drug use,particularly cocaine and/or associated toxic contaminants. |
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acquired immunodeficiency syndrome basal ganglia basal ganglia,lesion of basal ganglia,lesion,bilateral caudate nucleus,lesion of caudate nucleus,lesion of,bilateral cerebral ischemia human immunodeficiency virus type 1 microinfarcts MRI MRI,abnormal MRI,high signal foci on MRI,high signal intensity of basal ganglia neuropathology putamen,lesion of putamen,lesion of,bilateral seizure striatum,lesion of striatum,lesion of,bilateral
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