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Regress of HIV Enceph & Basal Ganglia Signal Intensity Abnor MRI in AIDS after Protease Inhibitor
Neuroradiology 206:491-498, Filippi,C.G.,et al, 1998
See this aricle in Pubmed

Article Abstract
Of the nine patients receiving protease inhibitors,four showed nearly complete regression,four showed interval stability,and one showed slight progression.Thus,eight patients(89%)demonstrated either stability or improvement in white matter disease,which correlated with cognitive improvement.Of the seven patients not receiving protease inhibitors,six (86%)showed marked progression with a decline in cognitive function and one had no interval change.The difference between the two groups was statistically significant.Of the two patients receiving protease inhibitors who initially had basal ganglia signal intensity abnormalities, one demonstrated resolution and one nearly complete resolution subsequently.Although the patient population is small,protease inhibitors may cause regression of periventricular white matter and basal ganglia signal intensity abnormalities in HIV encephalopathy and may have a role in treatment.
 
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acquired immunodeficiency syndrome
acquired immunodeficiency syndrome dementia complex
basal ganglia
basal ganglia,lesion of
CD4 counts
encephalitis,human immunodeficiency virus type 1
encephalopathy
human immunodeficiency virus type 1
MRI
MRI,abnormal
MRI,disappearing lesion on
MRI,high signal intensity of basal ganglia
MRI,serial
protease inhibitor,HIV-1
treatment of neurologic disorder
white matter disease

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